A biotech company pioneering transposases for cell line engineering claims to have widened the applications of these tools. Oren Beske, PhD, gave a talk at BioProcess International, about how ATUM is ...

Host Cell Line Selection: The first critical step is selecting the appropriate host cell line. This decision is based on factors such as growth characteristics, genetic stability, and productivity, ...

To date, more than 100 clinical trials with human pluripotent stem cell (hPSC)-derived products have been initiated worldwide and an increasing number of potential hPSC-derived clinical products have ...

Plant cell-based bioproduction systems are known for producing proteins with proper folding and post-translational modifications that have been used in a handful of approved therapeutics. Widespread ...

Multibillion-dollar gene therapy market facing critical manufacturing bottleneck that limits reach of lifesaving therapies to patients VectorSelect™ platform has the potential to revolutionize the ...

Advances in cell line engineering and microfluidic technologies offer substantial opportunities to shorten timelines in cell line development (CLD). However, as with any innovation, optimizing these ...

A new proof-of-concept method reliably engineered a hotspot mutation of SF3B1, a gene-splicing gene, into diverse cancer cell lines, outperforming other contemporary editing approaches. Oncogenesis ...