A compact Cas12f nuclease shows high editing efficiency in human cells, with structural insights enabling an engineered variant potentially suited for future AAV‑compatible delivery.

A research team led by geneticist Jeannie Lee at Harvard Medical School, cell biologist Jeanne Lawrence at UMass Chan Medical ...

Lehigh University bioengineering researcher Tomas Gonzalez-Fernandez, an assistant professor in the P.C. Rossin College of Engineering and Applied Science leads an interdisciplinary team applying ...

For the millions of people living with genetic diseases like muscular dystrophy and inherited liver disorders, one of the ...

Like the find-and-replace feature of a word processor, CRISPR-based engineering allows scientists to quickly and efficiently edit DNA sequences with base pair precision. Lauded as the great ...

Natural Killer (NK) cells are a critical component of the innate immune system and play an essential role in recognizing and eliminating cancer cells. Despite their promise, current NK-based therapies ...

By using CRISPR/Cas9 to engineer cells from healthy donors, AVC-203 is designed to circumvent graft-versus-host disease and host-mediated rejection.

CRISPR Therapeutics' Casgevy, the first CRISPR/Cas9 gene editing therapy, shows promising results in treating Sickle Cell Disease and beta thalassemia but faces challenges in patient adoption and cost ...