We evaluated a family in which five siblings were affected by autosomal recessive sensorineural hearing loss. Despite the presumably shared cause of the disorder, there were clinically significant ...

Boston, MA - The improvement of intracellular calcium cycling, through overexpression of the sarcoplasmic reticulum CA 2+ ATPase pump (SERCA2a), reduces arrhythmias and restores contractile function ...

The enzyme is the calcium-pumping Ca2+-ATPase - an ion pump protein that maintains a concentration of calcium inside the cell, which is about 20,000 times lower than outside. Only, it does not pump ...

High-speed pumps: Cells use high-speed pumps to pump calcium ions out of their interior. A team has created the first comprehensive transport model of plasma membrane CaATPase (PMCA) to study calcium ...