Fred Hutch

Study links common immune cell to failure of checkpoint inhibitors in lung cancer

For many lung cancer patients, the best treatment options involve checkpoint inhibitors. These immunotherapy drugs unleash a patient’s immune system against their disease and can yield dramatic ...
GEN

Checkpoint Protein Propped Up by Cell-Surface Sidekick

Many cancer cells duck the immune system’s T cells by displaying programmed death-ligand 1 (PD-L1), a cell-surface protein that engages programmed cell death protein 1 (PD-1), another cell-surface ...
Fred Hutch

CAR-T cells and checkpoint inhibitors: ripping out the breaks, or hitting the turbo?

Just like a runaway eighteen-wheeler on the interstate is a scary sight to behold, an immune system without brakes can quickly transform from a cherished protector to a host’s worst nightmare. To ...
Business Wire

City of Hope Study Finds a Novel Mechanism of Action for Natural Killer Cells in Checkpoint Inhibitor Therapy for Cancer

DUARTE, Calif.--(BUSINESS WIRE)--PD-L1 checkpoint inhibitors are a powerful and growing form of immunotherapy used to treat melanoma, kidney cancer, head and neck cancers, Hodgkin’s lymphoma and other ...
GEN

First-In-Class Immune Checkpoint Therapy Unlocks NK Cell Attack on Tumors

Scientists at Albert Einstein College of Medicine have developed a new anticancer strategy that they suggest could bolster the effectiveness of immune-checkpoint therapy. The team said their findings ...