Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome.

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome. Those interactions depend ...

This study analyzes the temporal dynamics of gene expression following TNF stimulation in macrophages. The work brings valuable data and new methodological approaches to implicate the splicing rate of ...

Our circadian clocks play a crucial role in our health and well-being, keeping our 24-hour biological cycles in sync with light and dark exposure. Disruptions in the rhythms of these clocks, as with ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

A study shows epigenetic proteins regulate genes through diverse dynamic patterns, not simple on-off control, with each ...

National Eye Institute researchers have uncovered how glucose metabolism in the retina influences gene expression in photoreceptors, offering new potential targets for age-related macular degeneration ...

National Eye Institute researchers have discovered that glucose metabolism in the retina directly influences gene expression in photoreceptor cells through specific epigenetic tags. The study shows ...