Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome.

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome. Those interactions depend ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Gene syntax alters DNA supercoiling to amplify or suppress nearby genes. This could improve the effectiveness of gene ...

The development offers a major technological advance in creating cell models of genetic diseases. The researchers used a modified version of CRISPR called CRISPR interference (CRISPRi) to inactivate ...

A study shows epigenetic proteins regulate genes through diverse dynamic patterns, not simple on-off control, with each ...

Our circadian clocks play a crucial role in our health and well-being, keeping our 24-hour biological cycles in sync with light and dark exposure. Disruptions in the rhythms of these clocks, as with ...

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

National Eye Institute researchers have uncovered how glucose metabolism in the retina influences gene expression in photoreceptors, offering new potential targets for age-related macular degeneration ...

A collaborative effort has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of ...

National Eye Institute (NEI) scientists have found that the way the retina metabolizes glucose directly controls which genes get switched on and off in light-sensing photoreceptors. The findings ...