Genetic modification aimed at understanding the function and pathology associated with specific genes is most commonly undertaken in mice, as about 99 percent of human genes have mouse orthologs. 1 ...

In the rapidly advancing field of immuno-oncology research, there has been increasing focus on the utility and optimization of cell humanized mice for translational research. Conventional murine ...

Since the development of the super immunodeficient CIEA NOG mouse® in the early 2000s enabled improved humanized immune system (HIS) mice, HIS models have been widely adopted in immuno-oncology ...

With a grant from NIH, the UC Davis Mouse Biology Program aims to create lab mice with aspects of the human immune system that allow them to support growth of the AIDS virus, HIV. These mice could be ...

The candidate gene FKBP5 is involved in the development of stress-related psychiatric disorders. A few years ago, researchers at the MPI discovered that it is increasingly activated in the brains of ...

Humanized immune system (HIS) mice are invaluable for advancing preclinical research, with various models available to support lymphoid, myeloid and/or specific cell populations. T and NK cells are ...

For the first time, scientists have successfully created a type of mouse with a 100% functional human immune system and human-like gut microbiome. This 'humanized' mouse takes the guesswork out of ...

Researchers have created a functional 'humanized' liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic ...

Currently developed cancer immunotherapies modify the interaction of cancer cells and the immune system, making drug testing targeting human cancer outside of clinical trials difficult. Kobe ...

A new study published in Microbiology Spectrum reports the establishment of a liver-humanized NSG-PiZ mouse model that is fully permissive to hepatitis B virus (HBV) infection. In this model, HBV can ...

Taconic Biosciences, Inc., a global leader in genetically engineered rodent models (GEMs) and humanized immune system (HIS) mouse models, today announced the acquisition of TransCure bioServices SAS, ...