Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous ...

Atherosclerosis represents a chronic inflammatory disease characterized by the accumulation of lipid-laden macrophage foam cells within arterial ...

In a recent study published in the Proceedings of the National Academy of Sciences Journal, researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral ...

This year’s Lasker Basic Medical Research Award recognizes the contributions of Drs. Richard Hynes, Erkki Ruoslahti, and Timothy Springer for their discovery and characterization of integrins, a major ...

An integrin mutation impairs skin T cell migration, enabling HPV proliferation that causes warts and lesions in a rare genetic dermatological condition.

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...

Johns Hopkins University biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute ...

Integrins are heterodimer transmembrane receptors for the extracellular matrix composed of an alpha and beta subunit. Natural integrin ligands include laminin, fibronectin, and vitronectin, but they ...

Scientists from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore have discovered the universal building blocks that cells use to form initial connections with the ...