The terms "intestinal barrier" and "intestinal permeability" describe two different aspects of the same anatomical structure, the intestinal wall composed of four layers, the mucosa, the submucosa, ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Deep in the folds of the intestine, in microscopic pockets called crypts, a quiet surveillance system is always at work. Stem cells lining the gut wall are not just rebuilding tissue—they are ...

The study demonstrated that AstraGin® helped to improve multiple indicators of intestinal barrier health. Treatment with AstraGin® resulted in increased transepithelial electrical resistance (TEER), ...

Necroptosis is critical for regulating intestinal epithelial cells (IECs). Butyric acid (BA), produced during intestinal microbial metabolism, protects the intestinal epithelial barrier. However, ...

A perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut ...

(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the ...

The farnesoid X receptor (FXR) is a nuclear receptor that plays a central role in bile acid regulation, intestinal barrier integrity, immune modulation and microbiome balance, all key factors involved ...

For much of modern medicine, inflammation was viewed as a localized response. Swelling, redness, and pain were understood as targeted reactions to injury or infection. Over time, however, researchers ...