When the replication machinery copies DNA, it must unwind the double helix in one direction while synthesis of one of the strands proceeds in the other. Making transient DNA loops may solve this ...

Undergraduate biology students could be forgiven for thinking that scientists have DNA replication all figured out. After all, textbooks present the models of replication so matter-of-factly that it's ...

DNA is duplicated within a complex macromolecular machine. Insights into how replication begins and how this is coordinated with progression of DNA synthesis come from a diverse range of sources. One ...