These findings are important as they show that affected muscles in an ALS mouse model remain receptive to reinnervation by healthy engrafted motor neurons, even until the late stages of the disease.

A research group conducted experiments using aged mice to demonstrate that muscle denervation at the neuromuscular junction (NMJ, *1) could be appreciably offset by an NMJ formation-enhancing ...

MIT scientists find that motor neuron growth increased significantly over 5 days in response to biochemical (left) and mechanical (right) signals related to exercise. The green ball represents cluster ...

Amyotrophic lateral sclerosis, or ALS, attacks nerve cells known as motor neurons in the brain and spinal cord, gradually leading to paralysis. The loss of function of an important gene, C9orf72, may ...

“Instead of inserting the corrected piece of information, we used CRISPR to cut DNA in two strategic places,” study coauthor Dwi Kemaladewi, a research fellow at the Hospital for Sick Children (Sick ...

The substantia nigra is a motor nucleus located in the basal ganglia of the midbrain. This brain structure contributes to the body's cognitive and motor functions by sending signals to initiate or ...

A research team has revealed that a molecule in the brain -- ophthalmic acid -- unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic ...

You may already be familiar with ALS, especially if you took part in the viral ice bucket challenge to raise awareness of the condition back in 2014. Now the disease, which currently has no cure, is ...

Injury to the spinal cord triggers a cascade of biological events that unfold within seconds and that proceed for months or even years. The events affect three major bodily systems: the nervous system ...

The obturator nerve is a large, multibranched nerve that travels through your pelvis to your inner thigh. This nerve helps you feel sensations like temperature and pain in your lower limbs. It also ...