The nuclear pore complex (NPC) is an essential, highly dynamic macromolecular assembly embedded in the nuclear envelope that orchestrates the precise exchange of proteins, RNA and other macromolecules ...

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins. Several types of cancer are believed to be linked to ...

Nuclear pore complexes are more dynamic than previously thought, reshaping our understanding of a vital transport process in cells. An international study led by the University of Basel (Switzerland) ...

In situ model of the nuclear pore complex transport barrier: Tethered within the pore are highly dynamic protein threads termed FG Nups (green). Under physiological conditions, cargo-carrying ...

In addition to exporting materials out of the nucleus, the protein, called Exportin-1 (also called Xpo1 or Crm1), seems to play a role in promoting gene transcription, the process that creates RNA ...

When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, researchers have known that protein quality control and damage to the nuclear ...

- Professors Hao F. Zhang and Xiaomin Bao’s groups used super-resolution imaging on human skin cells for the first time. - The researchers explored the gateways between the cells’ cytoplasm and ...

Proteins are most well-known for their intricate structures. The α-helices and β-sheets that form from interactions between sidechains create distinct shapes that, along with the specific amino acid ...