The evaluation of new drugs designed to treat specific anemias should include a thorough understanding of underlying pathophysiology, with a focus on enhancing oxygen transport. In this concise review ...

2,3-Diphosphoglycerate is present in the red cells of many species at about equimolar concentration to haemoglobin. It lowers the oxygen affinity and thus facilitates oxygen unloading because it is ...

Three patients heterozygous for hemoglobin Seattle were found to be anemic, with hematocrit levels of 24 to 33 per cent. Urinary erythropoietin excretion was 1 to 4 units per day. This low value ...