UConn Center on Aging researchers have published a new editorial in the journal Aging titled "Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer?" In ...

This is a preview. Log in through your library . Abstract Allopolyploidization, resulting in divergent genomes in the same cell, is believed to trigger a “genome shock”, leading to broad genetic and ...

The Drosophila melanogaster abdominal epithelium provides a good model for understanding how postmitotic diploid cells contribute to repair upon tissue damage. Losick et al. show that, after puncture ...

Our work highlights the need to study polyploidy and senescence in concert to understand their roles in aging, cancer, and ...

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies. Polyploidy often occurs in human diseases and cancers, and its ...