Imagine trying to design a key for a lock that is constantly changing its shape. That is the exact challenge we face in ...

High-resolution structures of nascent polypeptide chains in complex with the ribosome — the cell’s protein-synthesis machinery — reveal how the ribosome guides protein folding. Ribosomal attachment ...

Alan Herbert, Founder and President of InsideOutBio, discusses the evolution of biological concepts related to DNA and protein structures ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

For those outside the chemistry cognoscenti, the announcement might have seemed little more than researchers patting each other on the back. But the question of protein folding had plagued scientists ...

The latest short science news items from C&EN. Proteins are vital for life, involved in virtually every biochemical process that makes life possible. They comprise one or more amino acid chains ...

Proteins are the molecular machines of cells. They are produced in protein factories called ribosomes based on their blueprint, the genetic information. Here, the basic building blocks of proteins, ...

Protein folding raises some of biology's greatest theoretical challenges. It also lies at the root of many diseases. For example, the fundamental question of whether a protein's final tertiary ...

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of ...

Repeat proteins, defined by sequential arrays of short structural motifs, offer an intriguing departure from the folding behaviour of conventional globular proteins. Their modular architecture enables ...

Most of the activities that go on inside cells—the activities that keep us living, breathing, thinking animals—are handled by proteins. They allow cells to communicate with each other, run a cell’s ...