At the University of Oxford, scientists have developed a nanopore technology that can identify three different post-translational modifications (PTMs) in individual proteins, even deep within long ...

The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...

Protein AMPylation represents a specialised post‐translational modification (PTM) in which an adenosine monophosphate (AMP) moiety is covalently attached to specific amino acid residues on target ...

One of the main goals of proteomics is to unravel the many modifications important for biological activity. Post-translational modifications (PTMs) extend the range of protein function by attaching it ...

There is no known cure for Huntington's disease. A genetic mutation creates harmful proteins that accumulate and cause the disease's typical symptoms. A team from the Department of Human Genetics at ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds the host cell surface receptor angiotensin-converting enzyme 2 (ACE2). It is a glycosylated protein and is a target ...

Exploring the post-translational modifications of a key protein in Parkinson's disease, researchers uncover potential pathways for future therapies in neurodegenerative diseases in general.

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...

Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

One of the first things that students learn when they enter a biology class is the central dogma: DNA → messenger RNA → proteins. Only about 3% of the human genome directly codes for proteins, which ...