Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when ...

Spinocerebellar ataxias (SCAs) are a group of inherited neurodegenerative diseases that damage the spine and the cerebellum that sits just above it. The neuronal degeneration causes ataxia, or ...

How do the key features of protein folding, elucidated from studies on native, isolated proteins, manifest in cotranslational folding on the ribosome? Using a well-characterized family of homologous α ...

This is a preview. Log in through your library . Abstract High densities of ion channels at axon initial segments (AISs) and nodes of Ranvier are required for initiation, propagation, and modulation ...

Spectrin and ankyrin, two essential proteins, shape and fortify cell membranes. New findings on variations in spectrin's ability to bind to membranes have implications for new biomedical molecular ...

A network of proteins underlying the plasma membrane keeps epithelial cells in shape and maintains their orderly hexagonal packing in the mouse lens, according to new research. A network of proteins ...

Add Yahoo as a preferred source to see more of our stories on Google. The Penn State research team used advanced super‑resolution microscopy, a type of imaging technique that can peer into cells at ...

A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with a rare, debilitating disease of the nervous ...

Parent Project Muscular Dystrophy (PPMD), a nonprofit organization leading the fight to end Duchenne muscular dystrophy (Duchenne) awarded University of Washington a $148,000 grant to continue the ...

Spectrin and ankyrin are two essential proteins acting like bricks and mortar to shape and fortify cell membranes. But distinguishing which protein is the brick and which is the mortar has turned out ...

Neurons never sit still for long. Receptors move in and out of the cell surface. Signals surge, fade, then surge again. Beneath that activity, a fine lattice made of actin and spectrin quietly lines ...