Statistical methods now being used in adaptive biomarker-driven clinical trials are reviewed. Some previous paradigms for clinical trial design can limit the development of more effective methods on ...

Precision oncology exploits genomic, immunologic, and other biomarkers to drive discovery, drug development, and clinical care for patients with cancer. Precision oncology helps devise individualized ...

Here we offer a 'meta-methodology' and framework in which to evaluate epistemological foundations of proposed statistical methods. On the basis of this framework, we consider that many statistical ...