Synaptic pruning is a crucial neurodevelopmental process through which the brain refines its neural circuitry by systematically eliminating excess or weak synaptic connections. During early childhood ...

In the last five years, neuronal pentraxins have emerged as potential markers of synaptic loss. In the case of NPTX2, researchers may now be able to explain why. In the March 29 Science Translational ...

Synaptic pruning is the process in which the brain removes neurons and synapses that it does not need. This usually takes place when a person is 2–10 years old. The brain contains millions of neurons ...

The innate immune protein C1q seems to have a thing for neurons. Already implicated in synaptic pruning by microglia, now it is reported to also slow down protein production in neurons of the aging ...

A multidisciplinary team of scientists has discovered the mechanism that controls synaptic pruning of new neurons in the adult brain. The team discovered that microglial cells control the number of ...