Frontiers

TDP-43 and RNA-protein interactions: Advancing understanding and diagnosis in ALS pathogenesis

The field of neurodegenerative disease research has increasingly focused on the roles of RNA-binding proteins in the pathogenesis of amyotrophic lateral ...
Frontiers

Molecular mechanisms of Tau and TDP-43 pathology, and interaction of co-pathology in neurodegenerative disease

Neurodegeneration research has increasingly recognized the pivotal contributions of specific proteinopathies to cognitive decline and behavioral alterations ...

ALS may stem partly from failed protein cleanup in motor neurons

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the progressive loss of motor neurons, which ...
Hosted on MSN

AC Immune unveils first live brain images of TDP-43

Swiss biotech AC Immune has revealed Phase I results showing the first-ever in vivo images of TDP-43 protein in the human brain using its PET tracer ACI-19626. Presented at a leading Alzheimer’s and ...
GEN

ALS-Linked TDP-43 Aggregates Seen Clearly Enough to Raise Treatment Hopes

For the first time, the structure of a key player in amyotrophic lateral sclerosis (ALS), and multiple other neurodegenerative diseases, has been determined. The abnormal clumping of the TAR ...
ALZFORUM

CLIPs of TDP-43 Provide a Glimpse Into Pathology

TDP-43 scouts the nucleus like a roving film editor, splicing out introns from a slew of target RNAs. Researchers believe that identifying those targets will be key in determining how TDP-43 ...