Nature

p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma

PERP (p53 apoptosis effector related to PMP-22), a transcriptional target of p53, is downregulated and contributes to the impairment of apoptosis in uveal melanoma (UM). Intriguingly, PERP is not ...
Nature

p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm

The p53 family of transcription factors is composed of p53, p63 and p73. Despite conservation of functional domains, the family members are differentially involved in regulating processes such as ...
ascopubs.org

P63 in cytologic material is helpful for detection of squamous differentiation in non-small cell carcinomas of lung and treatment selection

Low incidence of brain metastasis as first site of relapse in patients with stage II and III non-small cell lung cancer No significant financial relationships to disclose. This is an ASCO Meeting ...
Science Daily

CRISPR screen reveals new targets in more than half of all squamous cell carcinomas

Researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of cancer. A little p63 goes a long ...

Biological shield can prevent skin cancer cells from transforming into aggressive metastatic forms

A new study has identified a molecular guardian that keeps skin cells from forgetting what they are and transforming into aggressive, migratory killers. By stabilizing a master genetic switch, this ...
ascopubs.org

p63/p73 expression mediates cisplatin sensitivity in a subset of triple-negative primary breast cancer: Implications for a new clinical trial

Ki-67 is a Luminal B marker that identifies a high-risk subgroup in hormone receptor positive and node negative breast cancer No significant financial relationships to disclose. This is an ASCO ...