Archaea represent a unique and ancient domain of life whose transcriptional regulation combines features of both bacterial and eukaryotic mechanisms. Unlike bacteria, many archaeal regulatory proteins ...

Osteoarthritis (OA) is the most common age-related joint disorder, affecting more than 500 million people worldwide and representing a leading cause of ...

Cellular homeostasis and stress response are tightly coordinated processes involving a complex interplay between signaling ...

This study is led by Professor XiaoqinLiu (Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agriculture Sciences, Shangdong, China). The authors explored ...

Nicotinamide adenine dinucleotide (NAD+) has long been conceptualized as a ubiquitous redox cofactor, embedded deeply within metabolic frameworks across living systems. More recent biochemical ...

In this valuable study, the authors develop new approaches to investigate mRNA imprinting, a phenomenon in which RNA-protein complexes form in the nucleus to influence the fate of transcripts in the ...

In the Alzheimer’s brain, microglia diversify into several activation states. What controls this specialization? In a preprint posted to bioRxiv on October 13, scientists led by Martin Kampmann at the ...

Using single-nucleus RNA sequencing, the authors map transcriptional changes in the rat ventral tegmental area following chronic inflammatory pain and acute morphine exposure. Notably, their ...