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JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, joined Jennifer Abbasi, director of JAMA Medical News, to discuss the most impactful, newsworthy, and novel studies published in JAMA over the past year, as selected by JAMA editors for the inaugural Research of the Year. Among the featured articles, a systematic review of 519 studies evaluating large language models (#LLMs) in health care found that only 5% used real patient data, with most focusing on medical knowledg