Sauna use could enhance our sensitivity to endorphins, not just by direct stimulation but also by initially making us uncomfortable. This discomfort is linked to the release of dynorphin, an endogenous opioid associated with dysphoria, which plays a role in the body’s heat response. When dynorphin binds to kappa-opioid receptors, it triggers a biological feedback that sensitizes the mu-opioid receptors to beta-endorphins. Consequently, repeated sauna sessions may increase mu-opioid receptor sens