ChIP-Seq Analysis: Histone Modifications

Histone Modifications - SlideServe

Histone modifications and gene expression - Lasker Foundation

Dr Vandana Puri on Instagram: "HDAC inhibitors (HDACi) are drugs that increase histone acetylation, leading to open chromatin and increased gene expression.HDAC enzymes normally remove acetyl groups → chromatin becomes tight → genes OFF HDAC inhibitors block this removal → chromatin becomes open → genes ON Common HDAC Inhibitors Vorinostat (SAHA) Romidepsin Panobinostat Belinostat Valproic Acid Vorinostat (SAHA) FDA-approved for cutaneous T-cell lymphoma. 2. Romidepsin Also used for T-cell lymph