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The American Association of Endodontists (AAE) advises that systemic antibiotics should only be used as an adjunct to definitive dental treatment (such as pulpectomy or extraction) for cases with systemic involvement (fever, malaise, rapid swelling, cellulitis) or in immunocompromised patients. They are not indicated for localized pain or irreversible pulpitis. https://www.aae.org/specialty/wp-content/uploads/sites/2/2017/06/aae_systemic-antibiotics.pdf https://www.aae.org/specialty/wp-content/u
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